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- Table of Contents
C-C motif chemokine 8 Antibodies
AND CCL8 ELISA kits, C-C motif chemokine 8 Proteins
Many biological assays use antibodies to detect C-C motif chemokine 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with C-C motif chemokine 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop C-C motif chemokine 8 antibodies...
Designing a Western blot for C-C motif chemokine 8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCL8 Western Blot GuideCCL8 Infographic by Boster Bio
All CCL8 Products
Product
Figures
Specificity
Applications
Price
Human CCL8/MCP-2 ELISA Kit PicoKine®
2 Citations
Human
ELISA
$499
Cat # EK0442
96 wells/kit, with removable strips.
Cat # EK0442
96 wells/kit, with removable strips.
Mouse CCL8/MCP-2 ELISA Kit PicoKine®
4 Citations
Mouse
ELISA
$499
Cat # EK1137
96 wells/kit, with removable strips.
Cat # EK1137
96 wells/kit, with removable strips.
CCL8 Overview
Facts about C-C motif chemokine 8.
C-C motif chemokine 8 (CCL8)
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses.
This protein can bind heparin. The processed form MCP-2(6-76) doesn't reveal monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCL8 |
| Uniprot: | P80075 |
| Entrez: | 6355 |
Family
| Belongs to: |
|---|
| intercrine beta (chemokine CC) family |
Alternative Names
C-C motif chemokine 8; CCL8; chemokine (C-C motif) ligand 8; HC14; MCP2; MCP-2; member 8 (monocyte chemotactic protein 2); monocyte chemoattractant protein 2; SCYA10; small-inducible cytokine A8
Molecular Weight
Mass (kDA):
11.246 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (34319435..34321402) |
Tissue Specificity
Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.
Subcellular Localizations
Secreted.
Diseases
- Inflammation
- Cholangiocarcinoma
- Neoplasms
- Hiv Infections
- Malignant Neoplasms
- Autoimmune Reaction
- Tissue Adhesions
- Sclerosis
- Inflammatory Response
- Multiple Sclerosis
- Immunologic Deficiency Syndromes
- Pertussis
- Asthma
Interacting Proteins
- CCL2
Pathways
- Chemotaxis
- Pathogenesis
- Immune Response
- Secretion
- Cell Migration
- Inflammatory Response
- Chemokine Production
- Cell Proliferation
- Cell Activation
- Chemokine Secretion
- Localization
- Granuloma Formation
- Monocyte Chemotaxis
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCL8
bosterbio.com/bosterbio-gene-info-cards/CCL8
References
PMID: 9119400 by van Coillie E., et al. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.
PMID: 9070881 by van Coillie E., et al. Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.
7 Publications of Boster C-C motif chemokine 8 Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1601062, Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed I...
- PubMed ID: 10.1016/j.brainresbull.2018.03.007, MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokin...
- PubMed ID: 10.1016/j.brainresbull.2017.10.009, Chemokine CCL8 and its receptor CCR5 in the spinal cord are involved in visceral...
- PubMed ID: 26585782 , Differential expression of inflammation-related genes in IL-4 transgenic mice be...
- PubMed ID: 24222374, Tu J, Yang L, Zhou X, Qi K, Wang J, Kouadir M, Xu L, Yin X, Zhao D. J Mol Neuros...
- PubMed ID: 25869610, Tu J, Chen B, Yang L, Qi K, Lu J, Zhao D. J Mol Neurosci. 2015 Jun;56(2):509-18....
- PubMed ID: 21647942, Xu Y, Feng L, Wang S, Zhu Q, Lin J, Lou C, Xiang P, He B, Zheng Z, Tang D, Zuo G...
*More publications can be found for each product on its corresponding product page