CIR1 Antibodies

AND CIR1 ELISA kits, CIR1 Proteins

Many biological assays use antibodies to detect CIR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CIR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CIR1 antibodies...

We validate the specificity of these antibodies to CIR1 by testing them on tissues known to express CIR1 positively and negatively. Browse below to find the CIR1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CIR1 Infographic by Boster Bio

All CIR1 Products

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Price

Anti-CIR Antibody (N-term)

Human

$299
Cat # A07268
80 µl

CIR1 Overview

Facts about Corepressor interacting with RBPJ 1.

CIR1 3D structure. Source: alphafold

Corepressor interacting with RBPJ 1 (CIR1)

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and functions as corepressor for RBPJ.

Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Information

Human
Gene Name:	CIR1
Uniprot:	Q86X95
Entrez:	9541

Family

Belongs to:

No superfamily

Alternative Names

CBF1 interacting corepressor; CBF1-interacting corepressor; CIRrecepin; corepressor interacting with RBPJ 1; corepressor interacting with RBPJ, 1; Recepin

Molecular Weight

Mass (kDA):
52.313 kDA

Genomic Context


Human

Location:	2q31.1
Sequence:	2; NC_000002.12 (174348022..174395712, complement)

Tissue Specificity

Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Subcellular Localizations

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with NEK6 in the centrosome.

Diseases

Infection By Cryptococcus Neoformans
Acquired Immunodeficiency Syndrome
Meningitis
Neoplasms
Meningitis, Cryptococcal
Plant Diseases
Cell Invasion
Cell Transformation, Neoplastic
Aids-related Opportunistic Infections
Iron Overload
Communicable Diseases

Retinitis Pigmentosa
Hodgkin Disease
Growth Acceleration
Meningoencephalitis
Nervousness

Interacting Proteins

CEP76
SRSF1
SRSF2
U2AF1

Pathways

Virulence
Pathogenesis
Regulation Of Gene Expression
Mating
Transport
Muscle Cell Differentiation
Circadian Rhythm
Electron Transport
Electron Transport Chain
Dna Methylation
Localization
Defense Response

Disease Resistance
Methylation
Reverse Transcription
Cell Differentiation
Histone Acetylation
Seed Germination
Germination

PTMs

Acetylation

Methylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CIR1

References

PMID: 9874765 by Hsieh J.J.-D., et al. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.

PMID: 10644367 by Zhou S., et al. A role for SKIP in EBNA2 activation of CBF1-repressed promoters.