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Dab2ip Antibodies
AND Dab2ip ELISA kits, Dab2ip Proteins
Many biological assays use antibodies to detect Dab2ip, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dab2ip in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dab2ip antibodies...
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Dab2ip Overview
Facts about Disabled homolog 2-interacting protein.
Disabled homolog 2-interacting protein (Dab2ip)
Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in a number of processes like innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation.
Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels leading to G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signs, like the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Dab2ip |
| Uniprot: | Q3UHC7 |
| Entrez: | 69601 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AIP1FLJ39072; ASK-interacting protein 1; DAB2 interacting protein; DAB2 interaction protein; DAB2-interacting protein; DIP1/2; disabled homolog 2-interacting protein; DOC-2/DAB2 interactive protein; KIAA1743AF9Q34ASK1-interacting protein 1; nGAP-like protein
Molecular Weight
Mass (kDA):
131.726 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 B |
| Sequence: | 2; |
Tissue Specificity
Expressed in vascular endothelium of muscle and aorta, in smooth muscle cells of aorta and epithelial cells of lung. Expressed throughout the brain, including olfactory bulb, hypothalamus, cerebellum and cerebral cortex. Expressed in the soma and processes of neurons in a variety of brain structures, including the developing cerebral cortex, CA1 pyramidal neurons and Purkinje cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Highly expressed in the brain, salivary gland, and testis; moderate expression in kidney and heart. Low expression in the lung, seminal vesicle, ventral prostate, epididymis, liver, and bladder. Very low expression in the coagulation gland and skeleton muscles. Lowest expression seen in spleen.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Liver Carcinoma
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
- Metastatic Prostate Cancer
- Cell Invasion
- Neoplasm Invasiveness
- Liver Neoplasms
Pathways
- Methylation
- Cell Proliferation
- Cell Death
- Cell Cycle
- Cell Growth
- Clathrin-mediated Endocytosis
- Dna Hypermethylation
- Gene Silencing
- Brain Development
- Histone Acetylation
- Dna Methylation
- Endocytosis
- Rna Interference
PTMs
- Methylation
- Phosphorylation
Research Areas
- Apoptosis
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dab2ip
bosterbio.com/bosterbio-gene-info-cards/Dab2ip
References
PMID: 16629596 by Chen H., et al. Cloning of mouse Dab2ip gene, a novel member of the RasGTPase- activating protein family and characterization of its regulatory region in prostate.
PMID: 23326475 by Qiao S., et al. Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum.