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Dapk2 Antibodies
AND Dapk2 ELISA kits, Dapk2 Proteins
Many biological assays use antibodies to detect Dapk2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dapk2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dapk2 antibodies...
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Dapk2 Infographic by Boster Bio
All Dapk2 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IF, IHC, WB
$523
Cat # M02241
100 µl
Cat # M02241
100 µl
Dapk2 Overview
Facts about Death-associated protein kinase 2.
Death-associated protein kinase 2 (Dapk2)
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that activate cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals.
The former involves caspase activation, chromatin and mitochondrial condensation while the latter entails caspase-independent cell death in conjunction with accumulation of adult autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta- catenin-dependent anchorage-independent growth of malignant epithelial cells.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Dapk2 |
| Uniprot: | Q8VDF3 |
| Entrez: | 13143 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DAP kinase 2; DAP-kinase-related protein 1 beta isoform; DAP-kinase-related protein 1; death-associated protein kinase 2; DRP1; DRP-1MGC119312; EC 2.7.11; EC 2.7.11.1
Molecular Weight
Mass (kDA):
42.778 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 9 C|9 35.75 cM |
| Sequence: | 9; |
Tissue Specificity
Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167).
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Lymphoma
- Hodgkin Disease
- Leukemia
- Stomach Neoplasms
- Adenoma
- Myeloid Leukemia, Chronic
Pathways
- Cell Death
- Neutrophil Differentiation
- Regulation Of Macroautophagy
- Macroautophagy
- Cell Proliferation
- Cellular Homeostasis
- Biological Regulation
PTMs
- Phosphorylation
Research Areas
- Apoptosis
- Autophagy
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dapk2
bosterbio.com/bosterbio-gene-info-cards/Dapk2
References
PMID: 10376525 by Kawai T., et al. Death-associated protein kinase 2 is a new calcium/calmodulin- dependent protein kinase that signals apoptosis through its catalytic activity.
PMID: 10629061 by Inbal B., et al. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.