DARS1 Antibodies

AND DARS1 ELISA kits, DARS1 Proteins

Many biological assays use antibodies to detect DARS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DARS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DARS1 antibodies...

We validate the specificity of these antibodies to DARS1 by testing them on tissues known to express DARS1 positively and negatively. Browse below to find the DARS1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DARS1 Infographic by Boster Bio

All DARS1 Products

Product

Figures

Specificity

Applications

Price

Human DARS Recombinant Protein

SDS-PAGE

$250
Cat # PROTP14868
Starting from 20ug

DARS1 (NM_001349) Human Over-expression Lysate

Human

$628
Cat # LS001615
100 µg

DARS1 Overview

Facts about Aspartate--tRNA ligase, cytoplasmic.

DARS1 3D structure. Source: alphafold

Aspartate--tRNA ligase, cytoplasmic (DARS1)

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. .

Gene Information

Human
Gene Name:	DARS1
Uniprot:	P14868
Entrez:	1615

Family

Belongs to:

class-II aminoacyl-tRNA synthetase family

Alternative Names

Aspartate--tRNA ligase, cytoplasmic

Molecular Weight

Mass (kDA):
57.136 kDA

Genomic Context


Human

Location:	2q21.3
Sequence:	2; NC_000002.12 (135905881..135985684, complement)

Tissue Specificity

Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.

Subcellular Localizations

Cytoplasm, cytosol.

Diseases

Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)

Interacting Proteins

AIMP2
FOXM1
GRB2

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DARS1

References

PMID: 2674137 by Jacobo-Molina A., et al. cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase.

PMID: 18029264 by Guzzo C.M., et al. Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro.