Protein DBF4 homolog A Antibodies

AND DBF4 ELISA kits, Protein DBF4 homolog A Proteins

Many biological assays use antibodies to detect Protein DBF4 homolog A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein DBF4 homolog A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein DBF4 homolog A antibodies...

We validate the specificity of these antibodies to Protein DBF4 homolog A by testing them on tissues known to express DBF4 positively and negatively. Browse below to find the DBF4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DBF4 Infographic by Boster Bio

All DBF4 Products

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Anti-Dbf4 (I18) Antibody

Western blot (WB) analysis of Dbf4 (I18) pAb at 1:500 dilution
Lane1:HEK293T whole cell lysate(40ug)
Lane2:PC3 whole cell lysate(40ug)
Lane3:The Testis tissue lysate of Mouse(40ug)
Lane4:The Testis tissue lysate of Rat(40ug)

Human, Mouse, Rat

IHC, WB

$405
Cat # A01348
100ul

Anti-DBF4 Antibody Picoband®

Western blot analysis of DBF4 using anti-DBF4 antibody (A01348-2)

IF analysis of DBF4 using anti-DBF4 antibody (A01348-2) and anti-Beta Tubulin antibody (M01857-3)

Flow Cytometry analysis of Raji cells using anti-DBF4 antibody (A01348-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A01348-2
100 μg/vial

Anti-DBF4 Rabbit Monoclonal Antibody

Western blot analysis of DBF4 expression in Jurkat cell lysate

Human

$370
Cat # M01348
100 μl/vial

DBF4 (NM_006716) Human Over-expression Lysate

Human

$628
Cat # LS010926
20 µg, 100 µg

DBF4 Overview

Facts about Protein DBF4 homolog A.

DBF4 3D structure. Source: alphafold

Protein DBF4 homolog A (DBF4)

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for development of S phase.

The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at'Ser-40' and'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. .

Gene Information

Human
Gene Name:	DBF4
Uniprot:	Q9UBU7
Entrez:	10926

Family

Belongs to:

No superfamily

Alternative Names

ASKchif; DBF4 homolog (S. cerevisiae); DBF4ACHIF; DBF4-type zinc finger-containing protein 1; ZDBF1DBF-type containing 1

Molecular Weight

Mass (kDA):
76.858 kDA

Genomic Context


Human

Location:	7q21.12
Sequence:	7; NC_000007.14 (87876493..87909553)

Tissue Specificity

Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Chromosomal Duplication
Ataxia
Tissue Adhesions
Neoplasm Metastasis
Melanoma
Hyperplastic Polyp
Genomic Instability
Suppressor Mutation
Physiological Stress
Ataxia Telangiectasia
Cutaneous Melanoma

Genotoxic Stress
Growth Arrest
Skin Neoplasms
Multiple Endocrine Neoplasia Type 1
Telangiectasis
Instabilities, Chromosomal
Immunologic Deficiency Syndromes

Interacting Proteins

CDC7

Pathways

Dna Replication
S Phase
Cell Cycle
Mitosis
G1 Phase
Meiosis
Cell Division
Cell Proliferation
Chromosome Segregation
Dna Replication Checkpoint
Dna Damage Checkpoint
Dna Repair
Meiosis I

Localization
Regulation Of Dna Replication
M Phase
Hyperphosphorylation
Dna Replication Initiation
Premeiotic Dna Replication
Proteolysis

PTMs

Phosphorylation
Cleavage

Dephosphorylation
Acetylation

Prenylation

Research Areas

Cell Cycle and Replication
Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DBF4

References

PMID: 10373557 by Kumagai H., et al. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.

PMID: 10523313 by Jiang W., et al. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.