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- Table of Contents
Spindlin-1 Antibodies
AND SPIN1 ELISA kits, Spindlin-1 Proteins
Many biological assays use antibodies to detect Spindlin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Spindlin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Spindlin-1 antibodies...
Designing an IHC experiment for Spindlin-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SPIN1 IHC GuideSPIN1 Infographic by Boster Bio
All SPIN1 Products
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SPIN1 Overview
Facts about Spindlin-1.
Spindlin-1 (SPIN1)
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated in'Lys-4' and asymmetrically dimethylated in'Arg-8' (H3K4me3 and H3R8me2a) and functions as an activator of Wnt signaling pathway downstream of PRMT2. In the event of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551).
Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006).
Gene Information
| Human | |
|---|---|
| Gene Name: | SPIN1 |
| Uniprot: | Q9Y657 |
| Entrez: | 10927 |
Family
| Belongs to: |
|---|
| SPIN/STSY family |
Alternative Names
OCR; spindlin 1; spindlin; spindlin-1; SPINOvarian cancer-related protein
Molecular Weight
Mass (kDA):
29.601 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.1 |
| Sequence: | 9; NC_000009.12 (88388444..88478694) |
Tissue Specificity
Highly expressed in ovarian cancer tissues.
Subcellular Localizations
Nucleus. Nucleus, nucleolus.
Diseases
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasms
- Neoplasms
- Head And Neck Carcinoma
- Carcinoma
Interacting Proteins
- HSPB1
Pathways
- Disease Resistance
- Programmed Cell Death
- Sperm Motility
- Cell Death
- Localization
- Spermatogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPIN1
bosterbio.com/bosterbio-gene-info-cards/SPIN1
References
PMID: 16098913 by Gao Y., et al. Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells.
PMID: 21960006 by Wang W., et al. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.