Protein DBF4 homolog B (DBF4B)

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases.

The intricate CDC7-DBF4B selectively phosphorylates MCM2 subunit in'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. .