DDB1- and CUL4-associated factor 1 (DCAF1)

Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an irregular serine/threonine-protein kinase, playing key roles in various processes like cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1- DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins like NF2.

Involved in the turnover of methylated proteins: recognizes and binds methylated proteins through its chromo domain, leading to ubiquitination of target proteins from the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination.