DCLRE1A Antibodies

AND DCLRE1A ELISA kits, DCLRE1A Proteins

Many biological assays use antibodies to detect DCLRE1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DCLRE1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DCLRE1A antibodies...

We validate the specificity of these antibodies to DCLRE1A by testing them on tissues known to express DCLRE1A positively and negatively. Browse below to find the DCLRE1A antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCLRE1A Infographic by Boster Bio

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DCLRE1A Overview

Facts about DNA cross-link repair 1A protein.

DCLRE1A 3D structure. Source: alphafold

DNA cross-link repair 1A protein (DCLRE1A)

May be required for DNA interstrand cross-link repair. Also needed for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.

Gene Information

Human
Gene Name:	DCLRE1A
Uniprot:	Q6PJP8
Entrez:	9937

Family

Belongs to:

DNA repair metallo-beta-lactamase (DRMBL) family

Alternative Names

DNA cross-link repair 1A; hSNM1; hSNM1A; KIAA0086SNM1 homolog A; PSO2 homolog; SNM1S. cerevisiae)

Molecular Weight

Mass (kDA):
116.4 kDA

Genomic Context


Human

Location:	10q25.3
Sequence:	10; NC_000010.11 (113834725..113854394, complement)

Tissue Specificity

Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.

Subcellular Localizations

Nucleus. In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.

Diseases

Fanconi Anemia
Anemia
Genomic Instability
Neoplasms
Lymphoma
Infective Disorder
Cell Transformation, Neoplastic
Immunologic Deficiency Syndromes
Severe Combined Immunodeficiency
Headache

Cytogenetic Abnormality
Congenital Combined Immunodeficiency
Bacterial Infections
Immune System Diseases

Pathways

Dna Repair
Cell Cycle
V(d)j Recombination
Cell Cycle Checkpoint
Telomere Maintenance
Prophase
Mitotic Cell Cycle
Chromosome Condensation

Double-strand Break Repair
Protein Ubiquitination

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

Research Areas

DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCLRE1A

References

PMID: 10848582 by Dronkert M.L.G., et al. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.

PMID: 12509242 by Zhang X., et al. Translation of hSNM1 is mediated by an internal ribosome entry site that upregulates expression during mitosis.