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- Table of Contents
mRNA-decapping enzyme 1A Antibodies
AND DCP1A ELISA kits, mRNA-decapping enzyme 1A Proteins
Many biological assays use antibodies to detect mRNA-decapping enzyme 1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with mRNA-decapping enzyme 1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop mRNA-decapping enzyme 1A antibodies...
Designing a Western blot for mRNA-decapping enzyme 1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DCP1A Western Blot GuideDCP1A Infographic by Boster Bio
All DCP1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04587-2
100 μg/vial
Cat # A04587-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04587
100 μl
Cat # M04587
100 μl
DCP1A Overview
Facts about mRNA-decapping enzyme 1A.
mRNA-decapping enzyme 1A (DCP1A)
Necessary for the degradation of mRNAs, both in ordinary mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP.
Contributes to the transactivation of target genes after stimulation by TGFB1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DCP1A |
| Uniprot: | Q9NPI6 |
| Entrez: | 55802 |
Family
| Belongs to: |
|---|
| DCP1 family |
Alternative Names
DCP1 decapping enzyme homolog A (S. cerevisiae); decapping enzyme hDcp1a; EC 3.-; FLJ21691; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIFHSA275986; Transcription factor SMIF
Molecular Weight
Mass (kDA):
63.278 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.1 |
| Sequence: | 3; NC_000003.12 (53283429..53347543, complement) |
Tissue Specificity
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Subcellular Localizations
Cytoplasm, P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
Diseases
- Physiological Stress
- Autoimmune Diseases
- Autoimmune Reaction
- Biliary Cirrhosis
- Primary Biliary Cirrhosis
- Liver Cirrhosis
- Malignant Neoplasms
- Neoplasms
- Dementia
- Stomatitis
- Infertility
- Hypokinesia
Interacting Proteins
- BAG4
- DCP1B
- DCP2
- DDX6
- EDC3
- EDC4
- FHL2
- NSMAF
- PNRC2
- RITA1
Pathways
- Localization
- Translation
- Gene Silencing
- Transport
- Mrna Processing
- Nuclear Export
- Mrna Transport
- Rna Processing
- Rna Interference
- Brain Development
- Regulation Of Gene Expression
- Reverse Transcription
- Cell Motility
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCP1A
bosterbio.com/bosterbio-gene-info-cards/DCP1A
References
PMID: 12417715 by Lykke-Andersen J.; Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
PMID: 11836524 by Bai R.-Y., et al. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.