- Table of Content
Acts by binding to cullin-RBX1 complexes in the cytoplasm and encouraging their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester into the complex, and optimizing the orientation of proteins in the complex to permit efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483).
|Sequence:||3; NC_000003.12 (182938074..182986364, complement)|
Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.