DDAH2 Antibodies

AND DDAH2 ELISA kits, DDAH2 Proteins

Many biological assays use antibodies to detect DDAH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDAH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDAH2 antibodies...

We validate the specificity of these antibodies to DDAH2 by testing them on tissues known to express DDAH2 positively and negatively. Browse below to find the DDAH2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DDAH2 Infographic by Boster Bio

All DDAH2 Products

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Specificity

Applications

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Anti-DDAH2 Antibody Picoband®

1 Q&As

Western blot analysis of DDAH2 using anti-DDAH2 antibody (PB10001)

IHC analysis of DDAH2 using anti-DDAH2 antibody (PB10001)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB10001
100 μg/vial

Anti-DDAH2 Monoclonal Antibody

6 Q&As

Western blot analysis of DDAH2 expression in MCF7 cell lysate

Human, Mouse, Rat

IP, WB

$370
Cat # M07566
100 μl

DDAH2 (NM_013974) Human Over-expression Lysate

Human

$628
Cat # LS023564
20 µg, 100 µg

DDAH2 Overview

Facts about N(G),N(G)-dimethylarginine dimethylaminohydrolase 2.

DDAH2 3D structure. Source: alphafold

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2)

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide production.

Gene Information

Human
Gene Name:	DDAH2
Uniprot:	O95865
Entrez:	23564

Family

Belongs to:

DDAH family

Alternative Names

DDAHII; dimethylargininase-2; dimethylarginine dimethylaminohydrolase 2G6a; dimethylarginine dimethylaminohydrolase II; EC 3.5.3.18; G6a; N(G); N(G)-dimethylarginine dimethylaminohydrolase 2; NG30; NG-dimethylarginine dimethylamino hydrolase homolog; S-phase protein

Molecular Weight

Mass (kDA):
29.644 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31727040..31730263, complement)

Tissue Specificity

Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.

Subcellular Localizations

Cytoplasm. Mitochondrion. Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.

Diseases

Hypertensive Disease
Cardiovascular Diseases
Diabetes Mellitus
Atherosclerosis
Diabetes Mellitus, Non-insulin-dependent
Pulmonary Hypertension
Hypertrophy
Hyperhomocysteinemia
Tumor Angiogenesis
Malignant Neoplasms
Pathologic Vasoconstriction
Right Ventricular Hypertrophy

Heart Diseases
Hemorrhage
Pheochromocytoma
Dysequilibrium Syndrome
Pathologic Neovascularization
Liver Cirrhosis
Idiopathic Pulmonary Hypertension

Interacting Proteins

TRIP13

Pathways

Methylation
Pathogenesis
Angiogenesis
Cell Differentiation
Dna Methylation
Regeneration
Acute Inflammatory Response
Cell Migration
Stem Cell Differentiation
Cellular Senescence
Aging
Immune Response
Tube Formation

Inflammatory Response
Cell Cycle
Vasoconstriction
Myoblast Differentiation
Chromatin Remodeling
Cell Proliferation
Localization

PTMs

Methylation
Reduction

Nitration
Phosphorylation

Glycosylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDAH2

References

PMID: 10493931 by Leiper J.M., et al. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.

PMID: 21898353 by Cillero-Pastor B., et al. Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes.