DDRGK domain-containing protein 1 (DDRGK1)

Protein that interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. During TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498).

May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity).