- Table of Content
TREX is recruited to spliced mRNAs with a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and can be recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to induce subsequent loading of elements like ALYREF/THOC and CHTOP on mRNA.
|DEAD box helicase family|
|Sequence:||6; NC_000006.12 (31530226..31542003, complement)|
Nucleus. Nucleus speckle. Cytoplasm. Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles.