Neutrophil defensin 4 Antibodies

AND DEFA4 ELISA kits, Neutrophil defensin 4 Proteins

Many biological assays use antibodies to detect Neutrophil defensin 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Neutrophil defensin 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Neutrophil defensin 4 antibodies...

We validate the specificity of these antibodies to Neutrophil defensin 4 by testing them on tissues known to express DEFA4 positively and negatively. Browse below to find the DEFA4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DEFA4 Infographic by Boster Bio

All DEFA4 Products

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Anti-Defensin alpha4 DEFA4 Antibody

4 Q&As

Immunohistochemistry analysis of Defensin α4 antibody in paraffin-embedded human heart tissue

Human, Mouse, Rat

ELISA, IF, IHC, ICC

$335
Cat # A06846
100ul

Anti-Defensin Alpha 4 (D27) DEFA4 Antibody

Immunohistochemistry (IHC) analyzes of Defensin α4 (D27) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50

Human, Mouse, Rat

IHC

$405
Cat # A06846-1
100ul

Neutrophil defensin 4 (DEFA4) (NM_001925) Human Over-expression Lysate

Human

$628
Cat # LS001669
20 µg, 100 µg

DEFA4 Overview

Facts about Neutrophil defensin 4.

DEFA4 3D structure. Source: alphafold

Neutrophil defensin 4 (DEFA4)

Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells from infection with HIV-1 (in vitro).

Inhibits corticotropin (ACTH)-stimulated corticosterone production. .

Gene Information

Human
Gene Name:	DEFA4
Uniprot:	P12838
Entrez:	1669

Family

Belongs to:

alpha-defensin family

Alternative Names

corticostatin; DEF4; defensin, alpha 4, corticostatin; defensin, alpha 4, preproprotein; HNP-4; HP4; HP-4; MGC120099; MGC138296; neutrophil defensin 4

Molecular Weight

Mass (kDA):
10.504 kDA

Genomic Context


Human

Location:	8p23.1
Sequence:	8; NC_000008.11 (6935820..6938306, complement)

Subcellular Localizations

Secreted.

Diseases

Salivary Gland Neoplasms
Infective Disorder
Adenoma
Cell Transformation, Neoplastic
Meningococcal Infections
Kidney Failure, Chronic
Malignant Paraganglionic Neoplasm

Mixed Salivary Gland Tumor
Dysequilibrium Syndrome

Pathways

Pathogenesis

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DEFA4

References

PMID: 8469233 by Palfree R.G.E., et al. The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8.

PMID: 2843187 by Singh A., et al. Structure of a novel human granulocyte peptide with anti-ACTH activity.