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- Table of Contents
Neutrophil defensin 4 Antibodies
AND DEFA4 ELISA kits, Neutrophil defensin 4 Proteins
Many biological assays use antibodies to detect Neutrophil defensin 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Neutrophil defensin 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Neutrophil defensin 4 antibodies...
Designing an IHC experiment for Neutrophil defensin 4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DEFA4 IHC GuideDEFA4 Infographic by Boster Bio
All DEFA4 Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS001669
20 µg, 100 µg
Cat # LS001669
20 µg, 100 µg
DEFA4 Overview
Facts about Neutrophil defensin 4.
Neutrophil defensin 4 (DEFA4)
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells from infection with HIV-1 (in vitro).
Inhibits corticotropin (ACTH)-stimulated corticosterone production. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DEFA4 |
| Uniprot: | P12838 |
| Entrez: | 1669 |
Family
| Belongs to: |
|---|
| alpha-defensin family |
Alternative Names
corticostatin; DEF4; defensin, alpha 4, corticostatin; defensin, alpha 4, preproprotein; HNP-4; HP4; HP-4; MGC120099; MGC138296; neutrophil defensin 4
Molecular Weight
Mass (kDA):
10.504 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (6935820..6938306, complement) |
Subcellular Localizations
Secreted.
Diseases
- Salivary Gland Neoplasms
- Infective Disorder
- Adenoma
- Cell Transformation, Neoplastic
- Meningococcal Infections
- Kidney Failure, Chronic
- Malignant Paraganglionic Neoplasm
Pathways
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DEFA4
bosterbio.com/bosterbio-gene-info-cards/DEFA4
References
PMID: 8469233 by Palfree R.G.E., et al. The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8.
PMID: 2843187 by Singh A., et al. Structure of a novel human granulocyte peptide with anti-ACTH activity.