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DENND4C Antibodies

AND DENND4C ELISA kits, DENND4C Proteins

Many biological assays use antibodies to detect DENND4C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DENND4C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DENND4C antibodies...

We validate the specificity of these antibodies to DENND4C by testing them on tissues known to express DENND4C positively and negatively. Browse below to find the DENND4C antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DENND4C Infographic by Boster Bio

DENND4C protein infographic

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DENND4C Overview

Facts about DENN domain-containing protein 4C.

DENND4C 3D structure

DENND4C 3D structure. Source: alphafold

DENN domain-containing protein 4C (DENND4C)

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 to its busy GTP-bound form.

Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. .

Gene Information

Human
Gene Name:	DENND4C
Uniprot:	Q5VZ89
Entrez:	55667

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

bA513M16.3; C9orf55B; DENN/MADD domain containing 4C; DKFZp686I09113; FLJ20686

Molecular Weight

Mass (kDA):
212.711 kDA

Molecular Weight

Genomic Context


Human

Location:	9p22.1
Sequence:	9; NC_000009.12 (19230693..19374281)

Subcellular Localizations

Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Associates with SLC2A4/GLUT4 storage vesicles.

Subcellular Localization

Diseases

Diabetes Mellitus, Non-insulin-dependent
Diabetes Mellitus

Disease

Pathways

Transport
Glucose Transport

Pathways

PTMs

Phosphorylation

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For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DENND4C

References

PMID: 20937701 by Yoshimura S., et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.