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DGUOK Antibodies
AND DGUOK ELISA kits, DGUOK Proteins
Many biological assays use antibodies to detect DGUOK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DGUOK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DGUOK antibodies...
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DGUOK Infographic by Boster Bio
All DGUOK Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS001716
20 µg, 100 µg
Cat # LS001716
20 µg, 100 µg
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A06092-1
100 μg/vial
Cat # A06092-1
100 μg/vial
DGUOK Overview
Facts about Deoxyguanosine kinase, mitochondrial.
Deoxyguanosine kinase, mitochondrial (DGUOK)
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the maximum efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2.
Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
Gene Information
| Human | |
|---|---|
| Gene Name: | DGUOK |
| Uniprot: | Q16854 |
| Entrez: | 1716 |
Family
| Belongs to: |
|---|
| DCK/DGK family |
Alternative Names
deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; DGK; dGKmitochondrial deoxyguanosine kinase; EC 2.7.1.113; MTDPS3
Molecular Weight
Mass (kDA):
32.056 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.1 |
| Sequence: | 2; NC_000002.12 (73926827..73958961) |
Tissue Specificity
Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
Subcellular Localizations
Mitochondrion.
Diseases
- Mitochondrial Diseases
- Mitochondrial Dna Depletion
- Dysmyelopoietic Syndromes
- Liver Failure
- Muscle Hypotonia
- Liver Diseases
- Nystagmus
- Hypoglycemia
- Hepatic Encephalopathy
- Liver Failure, Acute
- Mitochondrial Myopathies
- External Ophthalmoplegia
Pathways
- Oxidative Phosphorylation
- Transport
- Localization
- Dna Replication
- Pathogenesis
- Electron Transport
- Electron Transport Chain
- Dna Repair
- Nucleoside Salvage
- Cell Cycle Arrest
- Myelination
- Mitochondrial Dna Replication
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DGUOK
bosterbio.com/bosterbio-gene-info-cards/DGUOK
References
PMID: 8692979 by Johansson M., et al. Cloning and expression of human deoxyguanosine kinase cDNA.
PMID: 8706825 by Wang L., et al. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA.