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- Table of Contents
Facts about Dihydrofolate reductase 2, mitochondrial.
Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and of DHFR.
| Human | |
|---|---|
| Gene Name: | DHFR2 |
| Uniprot: | Q86XF0 |
| Entrez: | 200895 |

| Belongs to: |
|---|
| dihydrofolate reductase family |

DHFRP4; dihydrofolate reductase pseudogene 4; dihydrofolate reductase-like 1; dihydrofolate reductase-like protein 1; EC 1.5.1.-; EC 1.5.1.3; FLJ16119
Mass (kDA):
21.62 kDA

| Human | |
|---|---|
| Location: | 3q11.2 |
| Sequence: | 3; NC_000003.12 (94057922..94063389, complement) |
Expressed in numerous cell lines.
Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.




PMID: 21876188 by Anderson D.D., et al. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.
PMID: 21876184 by McEntee G., et al. The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.