- Table of Content
Attenuates MDM2-mediated p53/TP53 degradation, resulting in p53/TP53 stabilization and enhanced transcription activity, causing the accumulation of MDM2 and CDKN1A/p21. .
|short-chain dehydrogenases/reductases (SDR) family|
|Sequence:||14; NC_000014.9 (23630115..23645639)|
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Mitochondrion matrix. Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.