Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is exhibited in vitro with steroids, retinoids and sugars as substrates.

Attenuates MDM2-mediated p53/TP53 degradation, resulting in p53/TP53 stabilization and enhanced transcription activity, causing the accumulation of MDM2 and CDKN1A/p21. .