ATP-dependent DNA/RNA helicase DHX36 (Dhx36)

Proposed to have an international role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures.

Binds to quadruplex structures in the promoters of both YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an inner quadruplex formation in TERC 5'-end to market P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is interrupted by quadruplex formation.