Dixin Antibodies

AND DIXDC1 ELISA kits, Dixin Proteins

Many biological assays use antibodies to detect Dixin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dixin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dixin antibodies...

We validate the specificity of these antibodies to Dixin by testing them on tissues known to express DIXDC1 positively and negatively. Browse below to find the DIXDC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DIXDC1 Infographic by Boster Bio

All DIXDC1 Products

Product

Figures

Specificity

Applications

Price

Anti-DIXDC1 Mouse Monoclonal Antibody [Clone ID: OTI6B6]

Human, Monkey, Mouse, Rat

IF, IHC, WB

$523
Cat # M05992
100 µl

DIXDC1 (NM_001037954) Human Over-expression Lysate

Human

$960
Cat # LS085458
100 µg

DIXDC1 Overview

Facts about Dixin.

DIXDC1 3D structure. Source: alphafold

Dixin (DIXDC1)

Positive effector of the Wnt signaling pathway; activates WNT3A indicating via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Gene Information

Human
Gene Name:	DIXDC1
Uniprot:	Q155Q3
Entrez:	85458

Family

Belongs to:

DIXDC1 family

Alternative Names

Ccd1; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain containing 1; DIX domain-containing protein 1; Dixdc1; Dixin; Kiaa1735; KIAA1735coiled-coil-DIX1

Molecular Weight

Mass (kDA):
77.478 kDA

Genomic Context


Human

Location:	11q23.1
Sequence:	11; NC_000011.10 (111927144..112022653)

Tissue Specificity

Ubiquitously expressed with higher expression in cardiac and skeletal muscles.

Subcellular Localizations

Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745).; [Isoform 2]: Cytoplasm. Not associated with stress fibers.

Diseases

Malignant Neoplasms
Mental Disorders
Colonic Neoplasms
Malignant Tumor Of Colon
Carcinogenesis
Cell Transformation, Neoplastic
Schizophrenia
Abnormal Behavior
Malignant Neoplasm Of Breast
Polyps
Malignant Neoplasm Of Lung
Carcinoma
Intestinal Polyps

Neoplasms
Nervousness
Mammary Neoplasms
Colorectal Cancer
Sporadic Breast Carcinoma
Colorectal Adenocarcinoma
Adenocarcinoma

Interacting Proteins

DVL2
Dvl2

Pathways

Cell Proliferation
Neurogenesis
Cell Migration
Gliogenesis
Cell Cycle
Prepulse Inhibition
S Phase
Brain Development
Cell Growth

Interphase
Localization
Chromosome Segregation

PTMs

Phosphorylation

Ubiquitination

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DIXDC1

References

PMID: 16814745 by Wang X., et al. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein.

PMID: 15262978 by Wong C.K., et al. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.