Dickkopf-related protein 4 (DKK4)

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an significant role in vertebrate development, where they locally inhibit Wnt regulated processes like antero- posterior axial patterning, limb development, somitogenesis and eye formation.

In the mature, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .