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- Table of Contents
DLGAP5 Antibodies
AND DLGAP5 ELISA kits, DLGAP5 Proteins
Many biological assays use antibodies to detect DLGAP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DLGAP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DLGAP5 antibodies...
Designing a Western blot for DLGAP5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DLGAP5 Western Blot GuideDLGAP5 Infographic by Boster Bio
All DLGAP5 Products
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DLGAP5 Overview
Facts about Disks large-associated protein 5.
Disks large-associated protein 5 (DLGAP5)
Potential cell cycle regulator which may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway.
Key regulator of adherens junction integrity and distinction which may be involved in CDH1-mediated adhesion and signaling in epithelial cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DLGAP5 |
| Uniprot: | Q15398 |
| Entrez: | 9787 |
Family
| Belongs to: |
|---|
| SAPAP family |
Alternative Names
DAP-5; Discs large homolog 7; discs, large (Drosophila) homolog-associated protein 5; disks large-associated protein 5; DLG7; Hepatoma up-regulated protein; HURPDLG1; KIAA0008discs, large homolog 7 (Drosophila); large homolog 7
Molecular Weight
Mass (kDA):
95.115 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q22.3 |
| Sequence: | 14; NC_000014.9 (55148130..55191585, complement) |
Tissue Specificity
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Diseases
- Carcinoma
- Malignant Neoplasms
- Liver Carcinoma
- Neoplasms
- Liver Neoplasms
- Carcinogenesis
- Carcinoma, Transitional Cell
- Malignant Neoplasm Of Adrenal Cortex
- Tumors Of Adrenal Cortex
- Liver Regeneration Disorder
- Bladder Neoplasm
- Cell Transformation, Neoplastic
Interacting Proteins
- GOLGA2
- MTUS2
Pathways
- Spindle Assembly
- Mitosis
- Cell Cycle
- Anaphase
- Localization
- Metaphase
- Spindle Checkpoint
- Cell Proliferation
- Cell Death
- Transport
- Proteolysis
- Chromosome Segregation
- Nuclear Export
PTMs
- Phosphorylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLGAP5
bosterbio.com/bosterbio-gene-info-cards/DLGAP5
References
PMID: 12527899 by Tsou A.-P., et al. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.
PMID: 14699157 by Laprise P., et al. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.