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Key regulator of adherens junction integrity and distinction which may be involved in CDH1-mediated adhesion and signaling in epithelial cells. .
|Sequence:||14; NC_000014.9 (55148130..55191585, complement)|
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.