Dynein heavy chain 1, axonemal (DNAH1)

Force producing protein of cilia needed for sperm flagellum motility. Produces force to the minus ends of microtubules.

Dynein has ATPase activity; the force-producing power stroke is supposed to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).