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- Table of Contents
Facts about DnaJ homolog subfamily A member 1.
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573).
Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877).Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol into mitochondria in response to cellular stress, thereby protecting cells from apoptosis (PubMed:14752510).
Human | |
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Gene Name: | DNAJA1 |
Uniprot: | P31689 |
Entrez: | 3301 |
Belongs to: |
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No superfamily |
dj-2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1; DnaJ protein homolog 2; DNAJ2; HDJ2; hDJ-2; Heat shock 40 kDa protein 4; Heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ2; HSJ-2; HSPF4hdj-2; Human DnaJ protein 2; NEDD7; neural precursor cell expressed, developmentally down-regulated 7
Mass (kDA):
44.868 kDA
Human | |
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Location: | 9p21.1 |
Sequence: | 9; NC_000009.12 (33025203..33039907) |
Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.
Membrane; Lipid-anchor. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion. Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei.
There are many biological assays for DNAJA1 using monoclonal and polyclonal antibodies to the DNAJA1 protein. DNAJA1 is found within many animal samples. Boster Bio, which has developed antibodies against DNAJA1 by using rabbit and mouse as test methods, has identified DNAJA1 in these samples. DNAJA1 is part of the HSPA1 gene family. It negatively regulates the transfer of BAX to mitochondria. BAX is an important protein that protects cells from apoptosis.
BosterBio DNAJA1 is a marker that combines a primary and a second antibody for dual labeling specimens. These antibodies can be used in tandem to allow researchers to ask more and gain context data for their answers. It is not enough to have a primary antibody detect DNAJA1 on a specimen. You will need a second antibody to identify DNAJA1's gene. BosterBio DNAJA1 marker combines secondary and primary antibodies in a single package.
DNAJA1 can be described as a common gene that is expressed in the brain. This gene is classified as one of three subtypes, monoclonal or polyclonal. Boster Bio antibodies recognize DNAJA1 on a variety samples from mice and rabbit. Boster bio DNAJA1 markers are found in the HSPA1B Protein, which is a cochaperone for DNAJA1. This protein negatively regulates BAX's translocation into mitochondria. BAX protects cells from cell death.
The new Picokine(r) Quick ELISA Kit from Boster Bio is an upgrade from conventional ELISA kits. These kits combine sample incubation with detection antibody in a single step and can deliver excellent results in less than 1.5 hours. PicoKine(r), Quick ELISA kit is validated against a wide range biological samples and is guaranteed to be accurate.
DNAJA1 is a protein found in the blood of animals, plants, and humans. DNAJA1 ELISA kit detects the concentration of DNAJA1 liquid samples. ELISA kit provide three types information: a concentration level, a range, and a curve. These tools are useful in the research community. They're based on high-quality antibodies, which are highly specific for DNAJA1.
Picokine(tm), 96 -well ELISA Kits are available for detection of DNAJA1 These ELISA tests are fast to complete and provide high sensitivity, specificity, stability. They can be used in a wide variety biological samples. The highly standardized procedures guarantee precise results.
These ELISA tests can be used with a variety of samples, including plasma, cell lysate or tissue. They must also detect the marker in a broad range of samples without cross-reactivity or interference. These features are critical for accurate results. These ELISA kits can also be customized to suit your needs by providing sample preparation guides or standard curve preparation instructions.
In addition to high sensitivity, ELISA kits with picogram level reactivity for DNAJA1 are also designed for a wide range of samples, including serum, plasma, cell lysate, and tissue. Picokine (tm) technology improves the binding efficiency of these kits to target antigens and reduces non-specific binding. These kits can be purchased from tebubio and other top manufacturers.
ELISA kits allow for the detection of hundreds specific analytes. The kits contain pre-coated immune-plates, detection antibody, buffers and standards. An ELISA kit containing DNAJA1 markers contains a plate containing a sample diluent and capture antibody. Each strip well is equipped with a standard curve for reliable results.
ELISA is a great tool for high-sensitivity quantification. These tests can be used to detect the presence or absence of biologically important molecules. They are reliable and highly sensitive. Among their top qualities are the low CV values of ELISAs and their affordability. The following information will guide you in choosing the best ELISA Kit for your research. What are you waiting to do? Get your DNAJA1 EISA today! You'll be happy you did!
These ELISA kits can also measure the amount of a particular protein in the blood, which is known as NfL. They can also be used to detect brain injury. The digital ELISA test has a longer LLOD, which allows for a greater sensitivity and better reliability. The sensitivity and specificity of the tests are higher than those of conventional ELISAs.
Commercial ELISA kits are typically available in 96-well plate formats. They are simple to use, and require little training. They are easy to use and adaptable to various sample types. The ELISA technique relies on the interaction between the antigen (and its substrate). Because the antibody isn't labeled, it can detect antigen levels in a wide range samples, including plasma, serum, and tissue.
PMID: 8334161 by Oh S., et al. Human cDNA encoding DnaJ protein homologue.
PMID: 8334160 by Chellaiah A., et al. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein.