DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3)

Modulates apoptotic signal transduction or effector structures inside the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation.

Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging representative mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity.