- Table of Content
Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging representative mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity.
|Sequence:||16; NC_000016.10 (4425805..4456775)|
Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.