DNASE1L2 Antibodies

AND DNASE1L2 ELISA kits, DNASE1L2 Proteins

Many biological assays use antibodies to detect DNASE1L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNASE1L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNASE1L2 antibodies...

We validate the specificity of these antibodies to DNASE1L2 by testing them on tissues known to express DNASE1L2 positively and negatively. Browse below to find the DNASE1L2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DNASE1L2 Infographic by Boster Bio

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DNASE1L2 (NM_001374) Human Over-expression Lysate

Human

$628
Cat # LS001775
20 µg, 100 µg

DNASE1L2 Overview

Facts about Deoxyribonuclease-1-like 2.

DNASE1L2 3D structure. Source: alphafold

Deoxyribonuclease-1-like 2 (DNASE1L2)

Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune function by eliminating damaging DNA released into the extracellular environment by damaged epidermal cells.

Gene Information

Human
Gene Name:	DNASE1L2
Uniprot:	Q92874
Entrez:	1775

Family

Belongs to:

DNase I family

Alternative Names

Deoxyribonuclease-1-like 2

Molecular Weight

Mass (kDA):
32.853 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (2236444..2238711)

Tissue Specificity

Preferentially expressed in the skin and up- regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.

Subcellular Localizations

Cytoplasm. Secreted.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNASE1L2

References

PMID: 9205125 by Rodriguez A.M., et al. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.

PMID: 15203207 by Shiokawa D., et al. Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines.