Dedicator of cytokinesis protein 10 (DOCK10)

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway.

Sustains B-cell lymphopoiesis in secondary lymphoid cells and modulates FCER2/CD23 expression. .