DOCK10 Antibodies

AND DOCK10 ELISA kits, DOCK10 Proteins

Many biological assays use antibodies to detect DOCK10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK10 antibodies...

We validate the specificity of these antibodies to DOCK10 by testing them on tissues known to express DOCK10 positively and negatively. Browse below to find the DOCK10 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DOCK10 Infographic by Boster Bio

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DOCK10 Overview

Facts about Dedicator of cytokinesis protein 10.

DOCK10 3D structure. Source: alphafold

Dedicator of cytokinesis protein 10 (DOCK10)

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway.

Sustains B-cell lymphopoiesis in secondary lymphoid cells and modulates FCER2/CD23 expression. .

Gene Information

Human
Gene Name:	DOCK10
Uniprot:	Q96BY6
Entrez:	55619

Family

Belongs to:

DOCK family

Alternative Names

dedicator of cytokinesis 10; dedicator of cytokinesis protein 10; DKFZp781A1532; DRIP2; KIAA0694protein zizimin 3; Nbla10300; ZIZ3dopamine receptor interacting protein 2; zizimin3; zizimin-3

Molecular Weight

Mass (kDA):
249.531 kDA

Genomic Context


Human

Location:	2q36.2
Sequence:	2; NC_000002.12 (224765090..225042689, complement)

Tissue Specificity

Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.

Subcellular Localizations

Nucleus. Cytoplasm. Cell projection, dendritic spine.

Diseases

Cell Invasion
Neoplasms
Neoplasm Metastasis
Neoplasm Invasiveness
Carcinoma
Leukemia
Lymphoid Leukemia
Chronic Lymphocytic Leukemia
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Primary Neoplasm
Non-neoplastic Disorder
Melanoma

Tumor Progression
Head And Neck Carcinoma
Carcinoma, Papillary
Thyroid Neoplasm
Head And Neck Neoplasms
Papillary Thyroid Carcinoma
Malignant Neoplasm Of Thyroid

Pathways

Cytokinesis
Cell Division
Cell Proliferation
Response To Interleukin-4
Cell Motility
Anoikis

Proteolysis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK10

References

PMID: 18499258 by Yelo E., et al. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.

PMID: 21514340 by Alcaraz-Garcia M.J., et al. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.