Dolichol kinase Antibodies

AND DOLK ELISA kits, Dolichol kinase Proteins

Many biological assays use antibodies to detect Dolichol kinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dolichol kinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dolichol kinase antibodies...

We validate the specificity of these antibodies to Dolichol kinase by testing them on tissues known to express DOLK positively and negatively. Browse below to find the DOLK antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DOLK Infographic by Boster Bio

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DOLK (NM_014908) Human Over-expression Lysate

Human

$628
Cat # LS022845
20 µg, 100 µg

DOLK Overview

Facts about Dolichol kinase.

DOLK 3D structure. Source: alphafold

Dolichol kinase (DOLK)

Involved in the synthesis of the sugar donor Dol-P-Man that's required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. .

Gene Information

Human
Gene Name:	DOLK
Uniprot:	Q9UPQ8
Entrez:	22845

Family

Belongs to:

polyprenol kinase family

Alternative Names

SEC59 Homolog; CDG1M; DK; DK1; Dolichol Kinase 1; EC 2.7.1.108; KIAA1094; SEC59; TMEM15; Transmembrane Protein 15

Molecular Weight

Mass (kDA):
59.268 kDA

Genomic Context


Human

Location:	9q34.11
Sequence:	9; NC_000009.12 (128945530..128947603, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Congenital Disorders Of Glycosylation
Congenital Disorders
Cardiac Death
Strabismus
Hydrocephalus
Congenital Exomphalos
Congenital Hydrocephalus
Congenital Omphalocele
Dwarfism
Cleft Lip
Sudden Cardiac Death
Cerebral Palsy

Congenital Abnormality
Cardiomyopathy, Familial Idiopathic
Heart Failure
Cleft Palate
Anencephaly
Pathological Dilatation
Esotropia

Interacting Proteins

EDA
KCNA3
KCNA6
LRRC4C

Pathways

Glycosylation
Transport
Phototropism
Secretion

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOLK

References

PMID: 16923818 by Shridas P., et al. Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site.

PMID: 17273964 by Kranz C., et al. A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy.