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DOT1L Antibodies
AND DOT1L ELISA kits, DOT1L Proteins
Many biological assays use antibodies to detect DOT1L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOT1L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOT1L antibodies...
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DOT1L Overview
Facts about Histone-lysine N-methyltransferase, H3 lysine-79 specific.
Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L)
Histone methyltransferase. Methylates 'Lys-79' of histone H3.
Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).
Gene Information
| Human | |
|---|---|
| Gene Name: | DOT1L |
| Uniprot: | Q8TEK3 |
| Entrez: | 84444 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
DOT1L; DOT1-like protein; DOT1-like, histone H3 methyltransferase (S. cerevisiae); EC 2.1.1.43; H3-K79-HMTase; KIAA1814DKFZp586P1823; KMT4; KMT4H3 lysine-79 specific; Lysine N-methyltransferase 4
Molecular Weight
Mass (kDA):
164.856 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (2163933..2232578) |
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Malignant Neoplasms
- Leukemogenesis
- Chromosomal Translocation
- Cell Transformation, Neoplastic
- Neoplasms
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Acute Leukemia
- Leukemia, Experimental
- Acute Lymphocytic Leukemia
- Aneuploidy
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
Interacting Proteins
- MLLT1
- MLLT3
Pathways
- Methylation
- Cell Cycle
- Histone Methylation
- Histone Modification
- Transport
- Nuclear Export
- Localization
- Cell Cycle Checkpoint
- Regulation Of Gene Expression
- Demethylation
- Rna Processing
- Protein Phosphorylation
- Gene Silencing
PTMs
- Methylation
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOT1L
bosterbio.com/bosterbio-gene-info-cards/DOT1L
References
PMID: 12123582 by Feng Q., et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
PMID: 12693554 by Jikuya H., et al. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.