2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1)

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which happens in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and increase rate of ovarian cancer cells.

Acts also as a tumor suppressor in breast and lung cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).