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- Table of Contents
Ribonuclease 3 Antibodies
AND Drosha ELISA kits, Ribonuclease 3 Proteins
Many biological assays use antibodies to detect Ribonuclease 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ribonuclease 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ribonuclease 3 antibodies...
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Drosha Infographic by Boster Bio
All Drosha Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00111
100 μl
Cat # M00111
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00111-4
100 μg/vial
Cat # A00111-4
100 μg/vial
Drosha Overview
Facts about Ribonuclease 3.
Ribonuclease 3 (Drosha)
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Part of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to discharge precursor miRNA (pre-miRNA) from the nucleus.
Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing centre 11 bp from the dsRNA- ssRNA junction) to discharge hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to create mature miRNAs. Involved also in pre-rRNA processing.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Drosha |
| Uniprot: | Q5HZJ0 |
| Entrez: | 14000 |
Family
| Belongs to: |
|---|
| ribonuclease III family |
Alternative Names
drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; EC 3.1.26.3; ETOHI2; nuclear RNase III Drosha; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; RN3nuclear; RNase III
Molecular Weight
Mass (kDA):
158.828 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15|15 A1 |
| Sequence: | 15; |
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Ovarian Neoplasm
- Virus Diseases
- Digeorge Syndrome
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Malignant Neoplasm Of Ovary
- Carcinogenesis
Pathways
- Rna Interference
- Gene Silencing
- Translation
- Rna Processing
- Pathogenesis
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Growth
- Cell Death
- Spermatogenesis
- Regulation Of Gene Expression
- Oncogenesis
PTMs
- Cleavage
- Phosphorylation
- Methylation
Research Areas
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Drosha
bosterbio.com/bosterbio-gene-info-cards/Drosha
References
PMID: 19632182 by Gruber J.J., et al. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.
PMID: 26255770 by Du P., et al. A biogenesis step upstream of microprocessor controls miR-17~92 expression.