Desmocollin-2 Antibodies

AND DSC2 ELISA kits, Desmocollin-2 Proteins

Many biological assays use antibodies to detect Desmocollin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Desmocollin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Desmocollin-2 antibodies...

We validate the specificity of these antibodies to Desmocollin-2 by testing them on tissues known to express DSC2 positively and negatively. Browse below to find the DSC2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Desmocollin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DSC2 Western Blot Guide

DSC2 Infographic by Boster Bio

All DSC2 Products

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Product

Figures

Specificity

Applications

Price

Human DSC2 ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2187
96 wells/kit, with removable strips.

Anti-DSC2 Antibody Picoband®

Western blot analysis of Desmocollin 2/DSC2 using anti-Desmocollin 2/DSC2 antibody (A03205-2)

IHC analysis of Desmocollin 2/DSC2 using anti-Desmocollin 2/DSC2 antibody (A03205-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03205-2
100 μg/vial

Desmocollin 2 (DSC2) (NM_004949) Human Over-expression Lysate

Human

$960
Cat # LS001824
20 µg, 100 µg

Desmocollin 2 (DSC2) (NM_004949) Human Recombinant Protein

Coomassie blue staining of purified DSC2 protein

$1062
Cat # PROTQ02487
20 µg

DSC2 Overview

Facts about Desmocollin-2.

DSC2 3D structure. Source: alphafold

Desmocollin-2 (DSC2)

Part of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. .

Gene Information

Human
Gene Name:	DSC2
Uniprot:	Q02487
Entrez:	1824

Family

Belongs to:

No superfamily

Alternative Names

ARVD11; Cadherin family member 2; CDHF2; CDHF2DGII/III; desmocollin 2; Desmocollin2; Desmocollin-2; Desmocollin-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DSC2; DSC3DKFZp686I11137

Molecular Weight

Mass (kDA):
99.962 kDA

Genomic Context


Human

Location:	18q12.1
Sequence:	18; NC_000018.10 (31058840..31102421, complement)

Tissue Specificity

Expressed in epithelia, myocardium and lymph nodes.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Diseases

Arrhythmogenic Right Ventricular Dysplasia
Tissue Adhesions
Cardiomyopathies
Malignant Neoplasms
Neoplasms
Dental Plaque
Carcinoma
Cardiac Arrhythmia
Sudden Death
Sudden Cardiac Death
Cardiac Death

Neoplasm Metastasis
Dermatologic Disorders
Heart Failure
Malignant Squamous Cell Neoplasm
Pemphigus Foliaceus
Adenocarcinoma

Interacting Proteins

GJA1

Pathways

Cell Adhesion
Cell-cell Adhesion
Pathogenesis
Localization
Desmosome Assembly
Transport
Cell Proliferation
Demethylation
Dna Methylation
Methylation
Rna Interference
Keratinization
Epithelial Cell-cell Adhesion

Hair Follicle Development
Cell Migration
Programmed Cell Death
Dna Hypermethylation
Proteolysis
Immune Response
Pigmentation

PTMs

Cleavage
Demethylation

Methylation
Phosphorylation

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DSC2

References

PMID: 2037591 by Parker A.E., et al. Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing.

PMID: 17033975 by Syrris P., et al. Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2.