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Receptor for netrin required for axon guidance independently of and in cooperation with the receptor DCC. In spinal chord growth plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994).
|Sequence:||21; NC_000021.9 (40010999..40847158, complement)|
Primarily expressed in brain.
[Isoform Short]: Secreted.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell junction, synapse. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.