Probable E3 ubiquitin-protein ligase DTX2 (Dtx2)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, based on the developmental and cell context.

Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it might regulate the Notch pathway via some ubiquitin ligase activity (By similarity).