Probable E3 ubiquitin-protein ligase DTX3 (Dtx3)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, based on the developmental and cell context.

Functions as a ubiquitin ligase protein in vitro, suggesting that it might regulate the Notch pathway via some ubiquitin ligase activity. .