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- Table of Contents
Facts about EP300-interacting inhibitor of differentiation 2.
Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by blocking formation of TGFB-induced SMAD3-SMAD4 complex.
Human | |
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Gene Name: | EID2 |
Uniprot: | Q8N6I1 |
Entrez: | 163126 |
Belongs to: |
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No superfamily |
CREBBP/EP300 inhibitor 2E1A like inhibitor of differentiation 2; CREBBP/EP300 inhibitory protein 2; CRI2EP300-interacting inhibitor of differentiation 2; EID-2EID-1-like inhibitor of differentiation 2; EP300 interacting inhibitor of differentiation 2; MGC20452
Mass (kDA):
25.19 kDA
Human | |
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Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (39538707..39540161, complement) |
Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney.
Nucleus.
PMID: 14585496 by Ji A., et al. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD.
PMID: 12586827 by Miyake S., et al. A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation.