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- Table of Contents
Facts about Eukaryotic translation initiation factor 2 subunit 3.
This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex.
Human | |
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Gene Name: | EIF2S3 |
Uniprot: | P41091 |
Entrez: | 1968 |
Belongs to: |
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TRAFAC class translation factor GTPase superfamily |
EIF2; eIF-2gA; eIF-2-gamma X; EIF2gamma; EIF2Geukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD); eIF-2gX; eukaryotic translation initiation factor 2 subunit 3; Eukaryotic translation initiation factor 2 subunit gamma X; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G
Mass (kDA):
51.109 kDA
Human | |
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Location: | Xp22.11 |
Sequence: | X; NC_000023.11 (24054956..24078810) |
Expressed in testis, brain, liver and muscle.
PMID: 8106381 by Gaspar N.J., et al. Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit.
PMID: 9736774 by Ehrmann I.E., et al. Characterization of genes encoding translation initiation factor eIF- 2gamma in mouse and human: sex chromosome localization, escape from X- inactivation and evolution.