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ELF5 Antibodies
AND ELF5 ELISA kits, ELF5 Proteins
Many biological assays use antibodies to detect ELF5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ELF5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ELF5 antibodies...
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ELF5 Overview
Facts about ETS-related transcription factor Elf-5.
ETS-related transcription factor Elf-5 (ELF5)
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ELF5 |
| Uniprot: | Q9UKW6 |
| Entrez: | 2001 |
Family
| Belongs to: |
|---|
| ETS family |
Alternative Names
E74-like factor 5 (ets domain transcription factor); E74-like factor 5; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE2ESE-2; ETS-related transcription factor Elf-5
Molecular Weight
Mass (kDA):
31.263 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p13 |
| Sequence: | 11; NC_000011.10 (34478791..34513794, complement) |
Tissue Specificity
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Carcinoma
- Mammary Neoplasms, Experimental
- Kidney Neoplasm
- Dysequilibrium Syndrome
- Congenital Abnormality
- Prostatic Neoplasms
Pathways
- Methylation
- Mammary Gland Development
- Gland Development
- Lactation
- Dna Methylation
- Translation
- Cell Differentiation
- Fertilization
- Lung Development
- Transdifferentiation
- Cell Proliferation
- Pathogenesis
- Secretion
PTMs
- Methylation
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELF5
bosterbio.com/bosterbio-gene-info-cards/ELF5
References
PMID: 9840936 by Zhou J., et al. A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines.
PMID: 10506207 by Oettgen P., et al. Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.