Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a modest extent. The order of activity with various substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates.

Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP. .