This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Ectonucleoside triphosphate diphosphohydrolase 4.
Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP. .
| Human | |
|---|---|
| Gene Name: | ENTPD4 |
| Uniprot: | Q9Y227 |
| Entrez: | 9583 |

| Belongs to: |
|---|
| GDA1/CD39 NTPase family |

ectonucleoside triphosphate diphosphohydrolase 4; KIAA0392NTPDase 4; LALP70EC 3.6.1.6; LAP70guanosine-diphosphatase like protein; LYSAL1uridine-diphosphatase; lysosomal apyrase-like 1; Lysosomal apyrase-like protein of 70 kDa; NTPDase-4; UDPaseapyrase, lysosomal; Uridine-diphosphatase
Mass (kDA):
70.255 kDA

| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (23429152..23457731, complement) |
Ubiquitous. Highest expression in testis and lowest in bladder.
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Localizes in the Golgi and autophagic vacuoles/lysosomes.





PMID: 9556635 by Wang T.-F., et al. Golgi localization and functional expression of human uridine diphosphatase.
PMID: 10393803 by Biederbick A., et al. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles.