Elongin BC and Polycomb repressive complex 2-associated protein (Epop)

Scaffold protein that functions as a bridging partner involving the PRC2/EED-EZHtwo complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a crucial role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED- EZH2 complex (PubMed:27863225, PubMed:27863226).

Interaction with USP7 boosts deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766).