Epop Antibodies

AND Epop ELISA kits, Epop Proteins

Many biological assays use antibodies to detect Epop, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Epop in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Epop antibodies...

We validate the specificity of these antibodies to Epop by testing them on tissues known to express Epop positively and negatively. Browse below to find the Epop antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Epop Infographic by Boster Bio

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Epop Overview

Facts about Elongin BC and Polycomb repressive complex 2-associated protein.

Elongin BC and Polycomb repressive complex 2-associated protein (Epop)

Scaffold protein that functions as a bridging partner involving the PRC2/EED-EZHtwo complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a crucial role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED- EZH2 complex (PubMed:27863225, PubMed:27863226).

Interaction with USP7 boosts deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766).

Gene Information

Mouse
Gene Name:	Epop
Uniprot:	Q7TNS8
Entrez:	103551

Family

Belongs to:

No superfamily

Alternative Names

Elongin BC and Polycomb repressive complex 2-associated protein

Molecular Weight

Mass (kDA):
38.095 kDA

Genomic Context


Mouse

Location:	11\|11 D
Sequence:	11;

Tissue Specificity

Highly expressed in embryonic stem cells (ESCs) during embryogenesis and in the adult brain (PubMed:23180766).

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Epop

References

PMID: 21732481 by Zhang Z., et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

PMID: 23180766 by De Cegli R., et al. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.