Eppin Antibodies

AND EPPIN ELISA kits, Eppin Proteins

Many biological assays use antibodies to detect Eppin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Eppin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Eppin antibodies...

We validate the specificity of these antibodies to Eppin by testing them on tissues known to express EPPIN positively and negatively. Browse below to find the EPPIN antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EPPIN Infographic by Boster Bio

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SPINLW1 (EPPIN) (NM_020398) Human Over-expression Lysate

Human

$628
Cat # LS057119
20 µg, 100 µg

EPPIN Overview

Facts about Eppin.

EPPIN 3D structure. Source: alphafold

Eppin (EPPIN)

Serine protease inhibitor that plays an essential role in male fertility and reproduction. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial defense for spermatozoa in the semen coagulum, and contrasts SEMG1 thereby inhibiting sperm motility.

Gene Information

Human
Gene Name:	EPPIN
Uniprot:	O95925
Entrez:	57119

Family

Belongs to:

No superfamily

Alternative Names

Eppin

Molecular Weight

Mass (kDA):
15.284 kDA

Genomic Context


Human

Location:	20q13.12
Sequence:	20; NC_000020.11 (45540626..45547401, complement)

Tissue Specificity

In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.

Subcellular Localizations

[Isoform 1]: Secreted. Cell surface. Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPPIN

References

PMID: 11404006 by Richardson R.T., et al. Cloning and sequencing of human eppin: a novel family of protease inhibitors expressed in the epididymis and testis.

PMID: 15229136 by Yenugu S., et al. Antimicrobial activity of human EPPIN, an androgen-regulated, sperm- bound protein with a whey acidic protein motif.