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- Table of Contents
EPS15 Antibodies
AND EPS15 ELISA kits, EPS15 Proteins
Many biological assays use antibodies to detect EPS15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EPS15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EPS15 antibodies...
Designing a Western blot for EPS15? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EPS15 Western Blot GuideEPS15 Infographic by Boster Bio
All EPS15 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01681-1
100 μg/vial
Cat # A01681-1
100 μg/vial
EPS15 Overview
Facts about Epidermal growth factor receptor substrate 15.
Epidermal growth factor receptor substrate 15 (EPS15)
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation.
Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs).
Gene Information
| Human | |
|---|---|
| Gene Name: | EPS15 |
| Uniprot: | P42566 |
| Entrez: | 2060 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AF1P; AF-1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor pathway substrate 15; epidermal growth factor receptor substrate 15; Eps15; MLLT5; Protein AF-1p; Protein Eps15
Molecular Weight
Mass (kDA):
98.656 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p32.3 |
| Sequence: | 1; NC_000001.11 (51354263..51519275, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.; [Isoform 2]: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Colocalizes with HGS on bilayered clathrin coats on endosomes.
Diseases
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Myeloid Leukemia
- Cell Transformation, Neoplastic
- Hiv Infections
- Cell Invasion
- Cholera
- Nervousness
- Virus Diseases
- Liver Carcinoma
Interacting Proteins
- FCHO2
- Fcho2
- ITSN1
- NCK1
- PTPN3
- STON2
- UBQLN1
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Localization
- Transport
- Receptor-mediated Endocytosis
- Endocytic Recycling
- Pathogenesis
- Rna Interference
- Receptor Internalization
- Exocytosis
- Macropinocytosis
- Cell Adhesion
- Receptor Recycling
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPS15
bosterbio.com/bosterbio-gene-info-cards/EPS15
References
PMID: 8183552 by Wong W.T., et al. The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
PMID: 8134107 by Bernard O.A., et al. A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.