Epidermal growth factor receptor kinase substrate 8 (EPS8)

Signaling adapter which controls various cellular protrusions by regulating actin cytoskeleton architecture and dynamics. Depending on its association with other signal transducers, can modulate different processes.

Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling actions based on the context.