DNA excision repair protein ERCC-8 (ERCC8)

Substrate-recognition part of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complicated ) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent way; ERCC6 degradation is important for the recovery of RNA synthesis following transcription-coupled repair.

It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which eliminates RNA polymerase II-blocking lesions from the transcribed strand of active genes. .