ERVK-18 Antibodies

AND ERVK-18 ELISA kits, ERVK-18 Proteins

Many biological assays use antibodies to detect ERVK-18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERVK-18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERVK-18 antibodies...

We validate the specificity of these antibodies to ERVK-18 by testing them on tissues known to express ERVK-18 positively and negatively. Browse below to find the ERVK-18 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERVK-18 Infographic by Boster Bio

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ERVK-18 Overview

Facts about Endogenous retrovirus group K member 18 Env polyprotein.

ERVK-18 3D structure. Source: alphafold

Endogenous retrovirus group K member 18 Env polyprotein (ERVK-18)

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

This envelope protein has superantigenic properties. .

Gene Information

Human
Gene Name:	ERVK-18
Uniprot:	O42043
Entrez:	100775105

Family

Belongs to:

beta type-B retroviral envelope protein family

Alternative Names

Endogenous retrovirus group K member 18 Env polyprotein

Molecular Weight

Mass (kDA):
63.671 kDA

Genomic Context


Human

Location:	1q23.3
Sequence:	1;

Tissue Specificity

Expressed at higher level in the thymus. Expressed at lower level in peripheral blood lymphocytes.

Subcellular Localizations

[Transmembrane protein]: Cell membrane; Single-pass type I membrane protein.; [Surface protein]: Cell membrane; Peripheral membrane protein. The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM.; [Endogenous retrovirus group K member 18 Env polyprotein]: Virion.

PTMs

Cleavage on pair of basic residues

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERVK-18

References

PMID: 10516026 by Toenjes R.R., et al. Genome wide screening, cloning, chromosomal assignment and expression of full-length human endogenous retrovirus type K (HERV-K).

PMID: 11672541 by Stauffer Y., et al. Interferon-alpha induced endogenous superantigen: a model linking environment and autoimmunity.