Endogenous retrovirus group K member 25 Env polyprotein (ERVK-25)

Early post-infection, the reverse transcriptase converts the viral RNA genome to double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions.

It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome.