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Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a vital role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486).
|Location:||4 E2|4 82.9 cM|
Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dendritic spines. Expressed in utricle hair bundles (at protein level) (PubMed:26926603).