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- Table of Contents
ESRP1 Antibodies
AND ESRP1 ELISA kits, ESRP1 Proteins
Many biological assays use antibodies to detect ESRP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ESRP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ESRP1 antibodies...
Designing a Western blot for ESRP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ESRP1 Western Blot GuideDesigning an IHC experiment for ESRP1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ESRP1 IHC GuideESRP1 Infographic by Boster Bio
All ESRP1 Products
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ESRP1 Overview
Facts about Epithelial splicing regulatory protein 1.
Epithelial splicing regulatory protein 1 (ESRP1)
MRNA splicing factor that modulates the formation of epithelial cell-specific isoforms. Specifically modulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.
Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing throughout the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs.
Gene Information
| Human | |
|---|---|
| Gene Name: | ESRP1 |
| Uniprot: | Q6NXG1 |
| Entrez: | 54845 |
Family
| Belongs to: |
|---|
| ESRP family |
Alternative Names
epithelial splicing regulatory protein 1; FLJ20171; RBM35A; RMB35A; RNA binding motif protein 35A; RNA-binding motif protein 35A; RNA-binding protein 35A
Molecular Weight
Mass (kDA):
75.585 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q22.1 |
| Sequence: | 8; NC_000008.11 (94640999..94707466) |
Tissue Specificity
Epithelial cell-specific.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Invasion
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
- Stomach Neoplasms
- Growth Hormone-secreting Pituitary Adenoma
Interacting Proteins
- ATXN1
Pathways
- Cell Migration
- Developmental Process
- Cell-cell Adhesion
- Methylation
- Actin Cytoskeleton Organization
- Regulation Of Actin Cytoskeleton Organization
- Cytoskeleton Organization
- Regulation Of Cell Migration
- Dna Methylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ESRP1
bosterbio.com/bosterbio-gene-info-cards/ESRP1
References
PMID: 19285943 by Warzecha C.C., et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.
PMID: 29107558 by Rohacek A.M., et al. ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development.